Exploring the Impact of Anthropometric Measurements on Kidney Cancer Progression in Iraqi Patients: A Comprehensive Analysis

Main Article Content

Rana Kareem Mohammed
Salah Mohammed Fezea
https://orcid.org/0009-0005-7045-6809

Abstract

Despite not being digested, trace elements and/or heavy metals are important for the activity of enzymes, physiological processes, and homeostasis. If certain trace elements are present in excess, they can have harmful effects and pose major health hazards. Objective: The aims to examine the connection between serum zinc, copper levels, and the Cu/Zn ratio, and several anthropometric parameters, including an index of body mass and the waist-hip ratio. In our study, we used atomic absorption spectrometry (AAS) to measure serum levels of copper (Cu) and zinc (Zn) in 60 individuals, 30 patients with kidney cancer and 30 healthy controls. We assessed serum uric acid, creatinine, and urea using the semi-auto analyzer BA-88A (Korea). The results revealed a highly significant in the level of serum Cu, Zn and Cu/Zn ratio when compared with control, additionally high significant elevation in serum uric acid, creatinine and urea when compared with control. The result also indicates a prevalence of body mass index (BMI) and waist-hip-ratio (WHR) in patients with kidney cancer when compared with control. Our study compares blood levels of copper (Cu) and zinc (Zn) in kidney cancer patients to those in healthy controls. We aim to investigate any differences in the prevalence of these trace elements between the two groups, additionally of that a good relationship between BMI and WHR with serum Cu and Zn in the patient with kidney cancer. Current data reveal a significant prevalence of altered levels of copper (Cu), zinc (Zn), and the Cu/Zn ratio in patients with kidney cancer

Article Details

How to Cite
Kareem Mohammed, R., & Mohammed Fezea, S. (2025). Exploring the Impact of Anthropometric Measurements on Kidney Cancer Progression in Iraqi Patients: A Comprehensive Analysis. Tikrit Journal of Pure Science, 30(3), 42–48. Retrieved from https://www.tjpsj.org/index.php/tjps/article/view/1893
Section
Articles

References

1. MacInnis RJ, English DR, Hopper JL, Giles GG. Body size and composition and the risk of gastric and oesophageal adenocarcinoma. International journal of cancer. 2006;118(10):2628-31. https://doi.org/10.1002/ijc.21638

2. Ferlay J, Colombet M, Soerjomataram I, Dyba T, Randi G, Bettio M, et al. Cancer incidence and mortality patterns in Europe: Estimates for 40 countries and 25 major cancers in 2018. European journal of cancer. 2018;103:356-87.

https://doi.org/10.1016/j.ejca.2018.07.005

3. Zhang Y, Zheng J. Bioinformatics of metalloproteins and metalloproteomes. Molecules. 2020;25(15):3366. https://doi.org/10.3390/molecules25153366

4. Antwi‐Boasiako C, Dankwah GB, Aryee R, Hayfron‐Benjamin C, Aboagye G, Campbell AD. Correlation of lipid peroxidation and nitric oxide metabolites, trace elements, and antioxidant enzymes in patients with sickle cell disease. Journal of clinical laboratory analysis. 2020;34(7):e23294. https://doi.org/10.1002/jcla.23294

5. Suleman M, Khan A, Baqi A, Kakar MS, Ayub M. 2. Antioxidants, its role in preventing free radicals and infectious diseases in human body. Pure and Applied Biology (PAB). 2019;8(1):380-8. http://dx.doi.org/10.19045/bspab.2018.700197

6. Choi S, Liu X, Pan Z. Zinc deficiency and cellular oxidative stress: prognostic implications in cardiovascular diseases. Acta Pharmacologica Sinica. 2018;39(7):1120-32.

https://doi.org/10.1038/aps.2018.25

7. Ahmed SE, Maher FT, Naji NA. Effect of Thyroid Hormones and Trace Elements (Zn, Mg) on Obesity. Tikrit Journal of Pure Science. 2018;21(6):78-84. https://doi.org/10.25130/tjps.v21i6.1084

8. Xie Y, Xu P, Liu K, Lin S, Wang M, Tian T, et al. Hyperuricemia and gout are associated with cancer incidence and mortality: a meta‐analysis based on cohort studies. Journal of cellular physiology. 2019;234(8):14364-76.

https://doi.org/10.1002/jcp.28138

9. Ávila M, Mora Sánchez MG, Bernal Amador AS, Paniagua R. The Metabolism of Creatinine and Its Usefulness to Evaluate Kidney Function and Body Composition in Clinical Practice. Biomolecules. 2025;15(1):41. https://doi.org/10.3390/biom15010041

10. Weir C, Jan A. BMI Classification Percentile And Cut Off Points. En: StatPearls [Internet]. Treasure Island (FL). StatPearls Publishing; 2025. 11. Bray GA. Overweight is risking fate. Definition, classification, prevalence, and risks. Ann N Y Acad Sci. 1987;499:14-28.

https://doi.org/10.1111/j.1749-6632.1987.tb36194.x

12. Wang F, Xu Y. Body mass index and risk of renal cell cancer: a dose‐response meta‐analysis of published cohort studies. International journal of cancer. 2014;135(7):1673-86.

https://doi.org/10.1002/ijc.28813

13. Abdulla A, Sadida HQ, Jerobin J, Elfaki I, Mir R, Mirza S, et al. Unraveling molecular interconnections and identifying potential therapeutic targets of significance in obesity-cancer link. Journal of the National Cancer Center. 2024; 5(1):8-27. https://doi.org/10.1016/j.jncc.2024.11.001

14. Tiwari A, Balasundaram P. Public health considerations regarding obesity. 2021.

15. Du L, Zong Y, Li H, Wang Q, Xie L, Yang B, et al. Hyperuricemia and its related diseases: mechanisms and advances in therapy. Signal Transduction and Targeted Therapy. 2024;9(1):212. https://doi.org/10.1038/s41392-024-01916-y

16. Yim J, Son N-H, Kyong T, Park Y, Kim J-H. Muscle mass has a greater impact on serum creatinine levels in older males than in females. Heliyon. 2023;9(11).

https://doi.org/10.1016/j.heliyon.2023.e21866

17. Schwameis R, Postl M, Bekos C, Hefler L, Reinthaller A, Seebacher V, et al. Prognostic value of serum creatine level in patients with vulvar cancer. Scientific Reports. 2019;9(1):11129. https://doi.org/10.1038/s41598-019-47560-3

18. Hajaj E, Sciacovelli M, Frezza C, Erez A. The context-specific roles of urea cycle enzymes in tumorigenesis. Molecular cell. 2021;81(18):3749-59. https://doi.org/10.1016/j.molcel.2021.08.005

19. Kimura Y, Tsukui D, Kono H. Uric acid in inflammation and the pathogenesis of atherosclerosis. International journal of molecular sciences. 2021;22(22):12394.

https://doi.org/10.3390/ijms222212394

20. Khadem-Ansari M-H, Asoudeh M, Gheshlaghi HFK, Nozari S, Zarringol M, Maroufi NF, et al. Copper and zinc in stage I multiple myeloma: relation with ceruloplasmin, lipid peroxidation, and superoxide dismutase activity. Hormone molecular biology and clinical investigation. 2019;37(3):20180055. https://doi.org/10.1515/hmbci-2018-0055

21. Tang X, Yan Z, Miao Y, Ha W, Li Z, Yang L, et al. Copper in cancer: from limiting nutrient to therapeutic target. Frontiers in Oncology. 2023;13:1209156. https://doi.org/10.3389/fonc.2023.1209156

22. Mohsen AM, Ali ZA. Ceruloplasmin and some biochemical parameters as a marker for acute myeloid leukemic patients. Tikrit Journal of Pure Science. 2023;28(4):13-25.

https://doi.org/10.25130/tjps.v28i4.1526

23. Costa MI, Sarmento-Ribeiro AB, Gonçalves AC. Zinc: from biological functions to therapeutic potential. International Journal of Molecular Sciences. 2023;24(5):4822.

https://doi.org/10.3390/ijms24054822

24. Wang Y, Yu L, Ding J, Chen Y. Iron metabolism in cancer. International journal of molecular sciences. 2018;20(1):95.

https://doi.org/10.3390/ijms20010095

25. Abed MF. Investigating impact of industrial and agricultural activities on surface soil contamination using pollution indices, North Baiji City, Salah Alden Governorate, Iraq. Tikrit Journal of Pure Science. 2020;25(3):57-64.

https://doi.org/10.25130/tjps.v25i3.250

26. Laine JT, Tuomainen T-P, Salonen JT, Virtanen JK. Serum copper-to-zinc-ratio and risk of incident infection in men: the Kuopio Ischaemic Heart Disease Risk Factor Study. European journal of epidemiology. 2020;35:1149-56.

https://doi.org/10.1007/s10654-020-00644-1

27. Skalny AV, Timashev PS, Aschner M, Aaseth J, Chernova LN, Belyaev VE, et al. Serum zinc, copper, and other biometals are associated with COVID-19 severity markers. Metabolites. 2021;11(4):244. https://doi.org/10.3390/metabo11040244

28. Mohammed RK, Fezea SM. Determination of Some Trace Element Levels in Iraqi Male patients with Colorectal Cancer. Ibn AL-Haitham Journal For Pure and Applied Science. 2017;29(2):254-61.

29. Fadhel AA, Yousif AK. Correlation of glycated hemoglobin (Hba1c) and serum uric acid in type-2 diabetic patients. Indian Journal of Public Health. 2019;10(5):105. http://dx.doi.org/10.5958/0976-5506.2019.01167.7