Spectrophtometric determination of Hydrochlorothiazaide by oxidative coupling with O-Phenylendiamine
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Abstract
This study includes the development of a new sensitive spectrophotometric method for the determination of a hydrochlorothaizide in aqueous solution and pharmaceultical preparations. The method is based on the oxidative coupling reaction of hydrochlorothaizide with O-phenylendiamine reagent in a acidic medium pH 1.5 in the presence of potassium ferricyanide to produce an intense orange color, water soluble and stable product , which exhibits maximum absorption at 450 nm. Beer’s law is obeyed over the concentration arange 6 to 48 µg.ml-1 of hydrochlorothaizide, with a molar absorptivity of 3602.17 L.mo1-1 .cm -1 , Sandell’s sensitivity index of 0.03 µg.cm-2 , relative error range not more than 0.215% , and D.L 0.0835µg.ml-1 . The method has been successfully applied for the determination of hydrochlorothaizide in tablets.
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[1] SciFinder Databases: Registry, Chemcats. American Chemical Society. Available from: http://www.cas.org/products/scifinder,(2013).
[2] Neil, O.M.J. (2001). The Merck Index- An Encyclopedia of Chemicals, Drugs, and Biologicals, 13th edn. Whitehouse Station (NJ): Merck & Co., Inc.
[3] Chobanian, AV. et al. (2003). Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. National Heart, Lung, and Blood Institute; National High Blood Pressure Education Program Coordinating Committee (2003). Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension, 42(6): 1206–52.
[4] Mansia, G. et al. (2009). European Society of Hypertension. Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document. Journal Hypertens, 27(11): 2121–58.
[5] Combs, M.T.; Ashraf-Khorassani, M. and Taylor L.T. (1999). Journal Pharm. Biomed Anal., (19): 301-308.
[6] Dadfarnia, S.; Hajishabani, A. and Rad, H.F. (2011). Journal Chin. Chem. Soci., (58): 503-508.
[7] Valentina, G. et al. (2009). Anal. Chim. Acta, (1): 18-23.
[8] Kothacota, V. et al. (2011). Intern. Journal Pharm. Biolog., 2(4): 1167-1171.
[9] Jing, F.; Yahong, C.; Suling, F.; Cunling, Y. and Jianji, W. (2003). Anal. Sci., (19): 419-422.
[10] Ayman, H.K.; Sofia, A.A.; Goreti, M.F.S. and Felismina, T.C.M. (2009). Anal. Sci., (25): 365- 371.
[11] Martín, E.; Hernández, O.; Jiménez, F. and Arias, J.J. (2006). Simultaneous Spectrophotometric Determination of Hydrochlorothiazide and Pharmaceutical Preparations: 1449-1464.
[12] Sane, R.T. and Narkar, V.S. (2002). Indian Drugs, 18(23).
